Saint Denis

"A key gateway into North America with a trade route that runs the length of the country, the bustling city of Saint Denis is a melting pot of cultures and people where businessmen, socialites, sailors, laborers, beggars, and thieves all live side by side."

- Website description

Saint Denis is a location featured in Red Dead Redemption II. It is shown in the official gameplay trailer on a map and is the largest city in Bayou Nwa.

Trivia

 * This location appears to be based on New Orleans, Louisiana.