The Prodigal Son Returns (To Yale)

 is a mission in Red Dead Redemption.

Story
John goes to see the professor and while they're in his office Dutch shoots the window out and has the building and town surrounded with natives. The professor comes up with the idea of using the roofs to get to their horses which are in the alley way. So after busting into a room where two lovers are getting it the duo climb a ladder to the roof where the professsor is taken hostage, after you shoot the man whose taken the professor hostage you have to use a sniper rifle to take out all of Dutch's snipers. After the sniper shootout you jump across roof tops to the alley where you get on the horses. Marston and the professor high tail it to Manzanita post where the professor plans to take the next train straight to Yale. And of course as you are traveling to the post your atacked by natives on horseback. So in the end the professor makes it on to the train straight to Yale.

Walkthrough
After watching the opening cutscene climb the ladder onto the roof with MacDougal. Once you get on the roof the Professor is being held captive by one of Dutch's men. Go into Deadeye and take him out, then grab his sniper ammo if you need it and take out the enemies on the surrounding roof tops. Follow the Professor across the roofs and mount your horse (keep an eye out for the Carcano Sniper Rifle which is the best sniper Rifle in the game and obtaining it in this mission will save you $1100). Follow the professor out to the train station, shooting a few bandits off their horses along the way. Once you arrive at the train station you'll say farewell to the crazy professor and be on your way.