American Buffalo

 are an animal found in Red Dead Redemption. Like all animals found in the game, the can be hunted and skinned for profit or sport. Unlike other animals in the game, the Buffalo can be completely wiped out. They will not respawn once you get the Manifest Destiny achievement, so be sure to collect the skins of any buffalo you kill. You can find Buffalo's in the Old Plains but commonly roaming around the centre of the area. There is only one herd of Buffalo's in the game, and they quickly disperse after you begin shooting so using Dead Eye targeting system and aiming for multiple headshots is recommended.

The Buffalo is also the animal with the most valuable skinning products. Combined, the skin, horns, and meat of a buffalo can get you up to $68 at the highest, but then again, buffalos are not infinite.

Achievement/Trophy
The player must kill a to successfully complete the following achievement:
 * Unnatural Selection: Kill one of every animal species in the game in any game mode.
 * Manifest Destiny : Kill the last Buffalo in the Great Plains in Single Player.