Hopefully it follows a new, unrelated story, rather than airing out every single aspect of the same character and ultimately removing more and more excitement and reveal of the story unfolding.
The series has been edging further into the “end of the Wild West” as a theme, which can only go so far before it runs out completely. So my bet is that the next title will either be completely unrelated to the current characters (maybe a cameo with a nod and a wink here and there) if running concurrently, being set further in the past, or geographically displaced. There’s always the chance they pull a Quigley Down Under.