Depends, for hunting I usually either use the bolt action rifle or the bow, for combat it's usually either the lancaster repeater or the pump action shotgun

Sidearms are the schofield revolver (which I always try to get early on) and the semi-automatic pistol if I have it, if not then the sawed off shotgun

I like to preserve ammo as much as possible which is why I don't go for weapons with a fast firerate as much (especially since they're rarely necessary), but I do like to have one just in case I don't have enough time to aim and just need to spray and pray (for example in an encounter with the night folk, or a cougar if I happen to not be on my horse)

The guns on my horse are:

2 Double-action Revolvers

2 Semi-auto Pistols

2 Mausers

2 Schofields

John's Cattleman

Bolt-action & Carcano Rifle

Semi-auto Shotgun

Litchfield & Lancaster Repeater

My main loadout:

2 Double-Action Revolvers

Bolt-Action Rifle

Semi-Auto Shotgun

My go to load is. Either a pump or lever action shotgun, A linchfeild repeater, And two double action revovlers.

And a bow sometimes because there's always some kind of satisfaction by killing you foes with simple technology.