Personages in Red Dead Redemption bezitten allemaal verschillende karakters, gewoontes en individuele routines. John Marston ontmoet een verscheidenheid van verschillende personages in de game.
Hier volgt een lijst van alle personages:
- Abigail Marston
- Abner Forsyth
- Abraham Reyes
- Agustin Allende
- Aiden O'Leary
- Alma Horlick
- Alwyn Lloyd
- American Army Captain
- Amos
- Andreas Müller
- Andrew McAllister
- Annabel West
- Aquila
- Archer Fordham
- Basilio
- Benjamin Dupuis
- Bill Williamson
- Billy West
- Blackmailer
- Blackwater Guard dog
- Bonnie MacFarlane
- Carlos
- Carnelious Wolfe
- Charles Kinnear
- Charlie
- Chinese Immigrants
- Chow Hoy
- Clara LaGuerta
- Clyde Evans
- Cyrus Purvis
- D.S. MacKenna
- Dewey Greenwood
- Drew MacFarlane
- Dutch Van Der Linde
- Edgar Ross
- Eli
- Elizabeth Thornton
- Emilio Fortuna
- Emily Ross
- Errol Hewert
- Espinoza
- Eva Cortes
- Farmer MacGuffin
- Farmer MacGuffin's Daughter
- Francis Gallagher
- Floyd
- Floyds partner
- Gossiper
- Grace Anderson
- Harold MacDougal
- Harold Thornton
- Herbert Moon
- Howard Sawicki
- Irish
- Jack Marston
- Jake
- Javier Escuella
- Jeb Blankenship
- Jeb Murphy
- Jenny
- Jimmy Saint
- John Marston
- Jonah
- Juan de la Vara
- Landon Ricketts
- Leander Holland
- Lee Siu-Lung
- Leon Galindo
- Leigh Johnson
- Lucy
- Luisa Fortuna
- Manolo Santador
- Mario Alcalde
- Miranda Fortuna
- Moses Forth
- Mr. Fortuna
- Mrs. Bush
- Mrs. Ditkiss
- Mrs. Fortuna
- Muriel Scranton
- Nastas
- Nate Johns
- Nathaniel Johnston
- Nigel West Dickens
- Norman Deek
- Oliver Phillips
- Perro
- Peter Turner
- Phillip Ross
- Preacher
- Quique Montemayor
- Ralph Anderson
- Ramon
- Randall Forrester
- Raul Zubieta
- Rose Harling
- Rufus
- Sam Odessa
- Sam Wah
- Seth Briars
- Shaky
- Silas Spatchcock
- Strange Man
- Stranger
- Uncle
- Unnamed Woman
- Uriah Tollets
- Vincente de Santa
- Walton Lowe
- Zhou