In the beginning of the game, Arthur, Dutch and Micah visit the ranch to discover that the O'Driscolls killed Jake and that Sadie was hiding in the cellar to avoid certain death.
After the O'Driscolls are all slaughtered, Micah and Sadie get into a scuffle which results in Micah flipping a table with a gas lantern on top. This causes the lantern to burst, setting the property ablaze. After Arthur manages to calm down both Micah and Sadie, the gang take Sadie under their wing and escape from the burning home, retreating back to their camp at Colter.
Players can find jewelry in a lockbox within the burned-down residence, which can also be found when the ranch is introduced in Outlaws from the West.
The cheat code Death is silence is written on one of the burned beam of the house.