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American Venom is the final epilogue mission, as well as the final storyline mission in Red Dead Redemption 2.

Mission overview

Sadie Adler hears that Micah Bell is alive somewhere. With the whereabouts of Cleet known in Strawberry the gang saddles up looking for revenge. 

Story

Sadie, Charles, and John ride from Beechers Hope Ranch to Strawberry, where they find Cleet. The trio threatens to hang him if he doesn't reveal Micah's whereabouts, and in the end Cleet reveals that Micah along with his gang is at Mount Hagen. Cleet is then either hanged by John or shot by Sadie.

The three gunslingers travel to Mount Hagen, but as they prepare to begin hiking, Charles is shot and wounded. Sadie and John take cover and fight their way up the mountain with Charles in tow until disaster strikes. A group of Micah's men ambush them, and Sadie is shot in the leg. Charles kills her assailant, and tells John to keep going. After either knocking out or killing Joe, he storms the mountain and at last fights his way too the peak. John engages Micah in a gunfight, and neither can gain the upper-hand until Sadie arrives. Sadie puts Micah on gunpoint, and forces him to surrender, only for Dutch to arrive. Sadie, so surprised to see him, lets down her guard and Micah puts his gun to her head. Dutch then points his own gun at John, and John begs Dutch to help him, saying that Micah was the traitor all along. Dutch at last comes to his senses, shoots Micah, and walks away. John finishes off Micah, and then along with Sadie finds a massive fortune of gold left behind in the gang's hideout.

John, Sadie, and Charles ride back to the ranch, where they find Abigail and Jack. John tells her that its done, and the two finally get married. Charles and Sadie then depart, and are never seen again.

Gold Medal Objectives

  • Help Sadie catch Cleet within 35 seconds.
  • Headshot the sniper who shoots Charles.
  • Complete with at least 85% accuracy.
  • Complete the mission without taking any health items.

Deaths

  • Cleet - Hanged by John, or shot in the head by Sadie after revealing Micah's whereabouts.
  • Joe - Killed by John when trying to impede his journey to Micah's location.
  • Micah Bell - Jointly killed by Dutch (first), then by John in revenge for betraying the original gang as well as causing Arthur's death.

Video walkthrough

Trivia

  • The "Endless Summer" achievement/trophy, earned upon completion of the main storyline, is a nod to the endgame chapter of another Rockstar game, Bully.
  • After the mission is over, John and Abigail are seen conversing on the hill looking over the ranch; this very hill is used as John, Abigail, and Uncle's graves years later.
  • Once John reaches the mountain, he will change into the Winter Cowboy outfit, including Arthur's hat, suggesting John consciously chose to wear it for the confrontation.

Navigation

Red Dead Redemption 2 mission walkthroughs
Epilogue, Part 2: Beecher's Hope
"Bare Knuckle Friendships""An Honest Day's Labors""Home Improvement for Beginners""The Tool Box""A New Jerusalem""A Quick Favor for an Old Friend""Uncle's Bad Day""The Best of Women""Trying Again""A Really Big Bastard""A New Future Imagined""American Venom"
Chapter 1Chapter 2Chapter 3Chapter 4Chapter 5Chapter 6Epilogue, Part 1
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