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Heart from Brumas, the bear. Extremely rare and valuable.
In-game description

Brumas' Heart is an animal item found in Red Dead Redemption.


It is one of five items that can be obtained by killing and skinning the Legendary Animal known as Brumas the Bear.

Note: prices listed on this page are based upon the player having neutral honor and playing the game on Normal difficulty. If the player has high honor, the selling price will be Increased by 50% everywhere except Thieves' Landing. Low Honor decreases selling price by 50% everywhere except Thieves' Landing. While playing the game on Hardcore difficulty, money is more scarce and the base, neutral honor price of each item will be slightly lower.