Nothing is known of Josephine Bernier's background, only that she is the mother of Ira and Lewis Shelton based on her quotes.
Josephine Bernier can be found mostly in the BlackwaterBank doing paperwork. She can also be found in the Blackwater saloon drinking behind the counter. She is also found riding the blue Train and walking down off the train at MacFarlane's Ranch. She can also be seen in Armadillo probably visiting her sons.
A woman with the same character model as her, albeit recolored, can be seen all over New Austin.