The buildings at Macomb's End were constructed at some point prior to 1898.
Events of Red Dead Online
The protagonist can encounter Thomas, who is skiff captain from Lagras. Thomas asks the protagonist to help him to recover his boat, which was stolen by some men and located a Macomb's End.
Events of Red Dead Redemption 2
During "American Distillation", Arthur, Dutch, Bill and Archibald MacGregor head to the Fishing Spot to arrest a group of moonshiners. After blowing up their distillery, the nearby Lemoyne Raiders get their attention and Arthur and Bill head to Macamb's End to deal with them.
- On a crate on the pier is the Cigarette Card for the Parrot.
- A lockbox containing an apple, Chewing Tobacco, and money can be found beneath the floorboards of the eastern-most shack.
- The Legendary Ghost Panther can be found here in Red Dead Online.